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How Your Vitamin D Dosage Can Affect Breast Cancer

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Vitamin D can affect breast cancer

Vitamin D is an important nutrient that plays a significant role in the healthy functioning of the human body. Among other things, vitamin D helps improve muscle strength, boosts the immune system, promotes the absorption of calcium, and reduces inflammation. There is even an apparent connection between shortages of vitamin D and the development of certain kinds of cancers.

But what about breast cancer? Do vitamin D deficiencies increase a woman's vulnerability to this disease? For a long time, there has been a lot of disagreement over this question. Many vitamin D advocates have claimed that the nutrient's ability to prevent breast cancer has long been established, while mainstream medical sources have usually asserted the connection remains unproven.

As time has gone on, however, more evidence has begun to accumulate that suggests vitamin D levels can play a positive role in reducing the risk of breast cancer.

What is Vitamin D
Strictly speaking, vitamin D is not actually a vitamin at all. The substances that carry this label are known as prohormones, which means that they function as precursors to hormones that perform important tasks in the body once created. In human beings, most vitamin D is made naturally by the body as a result of exposure to ultraviolet radiation from the sun. Many dietary sources of vitamin D have actually been fortified with it (milk, cereal, juices, yogurt, etc.), although it can be found to some degree in things like fatty fish, eggs, and fish liver oil. Nevertheless, exposure to sunlight is the primary means by which humans acquire their supplies of this critically important nutrient.

Vitamin D that is obtained from food, supplements, and exposure to sun is biologically inert and must undergo activation in the body. This process occurs in two steps, one in the liver, and the other in the kidney forming the active 25-dihydroxyvitamin D 25(OH)D.

Vitamin D and Health
The importance of vitamin D for maintaining overall bone and general health was well established decades ago. In 2007, a group of vitamin D and nutrition researchers published an editorial stating that approximately 1,700IU/day of vitamin D is essential for general health. The intake reference value for vitamin D is called dietary reference intake (DRI). Vitamin D is found to prevent or slow the progression of osteoporosis and cancer.

Osteoporosis:
Osteoporosis causes weak bones and is associated with low calcium intake, and insufficient vitamin D can contribute to osteoporosis by reducing calcium absorption.

Cancer:
Early research studies and laboratory evidence suggested that vitamin D could affect cancer risk. Studies indicated that vitamin D plays a role in the prevention of colon, prostate, and breast cancers. Further studies showed epidemiologic data suggested that vitamin D may have a protective effect again colon cancer, but not so much for prostate and breast cancer. Further research continued and new studies have now shown that vitamin D inadequacy can result in cancer risk.

In 2007, a landmark study suggested that vitamin D could offer a highly effective way of cancer prevention. The study found that a combination of vitamin D3 and calcium has a positive effect of reducing cancer incidence. The study was promising in that it found a vitamin D supplement decreased cancer incidence in postmenopausal women by nearly 60 percent.

In November 2010, the Institute of Medicine (IOM) set new dietary intake levels for calcium and vitamin D to maintain health and avoid risk associated with excess use. IOM set the new limit at 600 international units (IU) of vitamin D per day for people up to age 70, and up to 800 IU for people aged 71 and older. The IOM committee reported that the majority of Americans are getting sufficient vitamin D.

Breast Cancer and Sunlight
France's version of the National Institute of Health recently reported on a research study they had done involving 67, 000 French women, 8,9000 of whom had suffered from breast cancer. This study was designed to see if exposure to sunlight could be linked to breast cancer rates in any way. It turns out that women who lived in the sunniest areas of southern France were 50% less likely to be diagnosed with breast cancer when compared to average rates. The researchers also looked at eating habits and vitamin D consumption, and found those women who received the majority of their vitamin D from sunlight instead of diet where 32% less likely to be diagnosed with breast cancer.

Geographical data reveals that women living in the sunny American Southwest have lower breast cancer rates than women living in the darker Northeast, and national breast cancer rates have been negatively correlated to distance from the equator (closer to the equator means more hours of sunlight). A study from Norway even found that women diagnosed with breast cancer in summer had better survival rates than those diagnosed in the winter, presumably because extra sunlight in the early stages of the disease can be decisive.

High Vitamin D Intake Needed to Reduce Cancer Risk
In February 2011, researchers at San Diego School of Medicine and Creighton University School of Medicine published results of another study that reported higher intake of vitamin D is required to reach blood levels that can markedly prevent the incidence of breast cancer and other major diseases. Dr. Cedric Garland of the UC San Diego Moores Cancer Center, said, “We found that daily intakes of vitamin D by adults in the range of 4000-8000 IU are needed to maintain blood levels of vitamin D metabolites in the range required to reduce the risk of several diseases - breast cancer, colon cancer, multiple sclerosis, and type 1 diabetes.” The study investigators noted that it will soon become common for adults to take 4000IU/day, and virtually everyone can take additional vitamin D to help prevent major types of cancer and other major illnesses.

While the IOM committee set the recommended daily intake of vitamin D at 600IU/day, it states that the 4000IU/day is a safe dose.

Conflicts in the Data
One Canadian study that measured vitamin D in the blood of women with breast cancer found that those with relatively high levels had a 50% reduction in their 12-year all-cause mortality rates compared to those with the lowest levels. Another report in the journal Cancer Epidemiology, Biomarkers and Prevention discussed research showing that patients with low amounts of vitamin D in their bloodstreams had more aggressive tumors and a higher risk of future breast cancer recurrence. There are some recent examples of research studies showing a positive connection between vitamin D and decreased breast cancer risk; but there are several other studies that have been done over the years that have produced similar results.

On the other hand, there have been many other studies that have not been able to find a connection between vitamin D and breast cancer prevention. This has naturally caused confusion and skepticism. But a 2008 report published in the Journal of Steroid Biochemistry and Molecular Biology may have revealed the key reason for the discrepancy between different studies. This meta-analysis of other studies found no protective effect for vitamin D against breast cancer in most cases. However, it did find a positive effect when the breast cancer rates of those with the highest levels of vitamin D in their bloodstreams were compared to women who had the lowest.

More Varied Research is Needed
It must be admitted there is a certain incompleteness in the research data on the vitamin D – breast cancer connection. For example, there is no clear recommendation that emerges about just exactly how much vitamin D would be needed to deliver significant protective effects. In part, this may be because cancer researchers have been too focused on drug-based approaches to treating breast cancer and have not put enough effort into really looking closely at the possibilities offered by natural substances and nutrients. This seems to have started changing, however, which may be why the general evidence supporting a positive connection between vitamin D and breast cancer rates now appears to be getting stronger.

Effect of Vitamin D Supplements on Joint Pain and Fatigue in Women with Breast Cancer
Vitamin D deficiency and insufficiency can contribute to musculoskeletal symptoms and some bone loss in postmenopausal women taking adjuvant therapy for breast cancer. The suboptimal levels of vitamin D can be supplemented safely with 50,000 IU of vitamin D3 each week that may significantly reduce bone and joint pains resulting from treatment.

Ask your doctor to check your vitamin D level and request supplementation to improve your symptoms. The new research is promising and every breast cancer patient must get additional supplementation to alleviate symptoms of fatigue and pain.

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