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Active and Passive Smoking Linked to Breast Cancer

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Smoking and second hand smoke linked to breast cancer

In many instances, strong or medium-strong connections have been shown to exist between breast cancer and various personal habits, lifestyle choices, genetic characteristics, and biological processes. When lists of risk factors for breast cancer are presented, they generally only include those factors that have been proven to a high degree of certainly to be linked to an increased incidence of the disease.

But what happens when the evidence is not so strong? Medical research has identified a number of factors that appear to have some connection to increased cancer risk, but the link is still not easy to establish for certain. This is usually because the amount of research done has been too limited, or because the apparent causal relationship is slight enough to cast doubt on the results. When situations like this arise, the most common approach is to mention the possible connection in passing, but to emphasize the fact that the causal link to the disease of the behavior, characteristic, or trait in question remains unproven.

One of the behaviors that falls into this category with respect to breast cancer is smoking. The connection between smoking and other types of conditions such as cancers of the lung, throat, and mouth are well-established. But with breast cancer the apparent link has seemed tenuous - many have speculated about a possible connection, but the evidence to prove it has been considered scanty and unimpressive.

In just the past few months, however, the picture has suddenly changed. The results of two new studies were released in 2011 that appear to show a noticeable and statistically significant relationship between smoking and an increased risk for breast cancer.

New Evidence
The first of these studies, released in January of 2011 and published in the Archives of Internal Medicine, has added important information to the debate about the connection between smoking and breast cancer. Researchers from Harvard were fortunate to have access to 30 years worth of data that had been collected about the health conditions and lifestyle patterns of over 110,000 women who participated in the massive and groundbreaking Nurses' Health Study. There were 8,772 cases of breast cancer diagnosed in this group during the period of time covered by the survey, and researchers looking at the data on the smoking habits of these women were careful to eliminate the possible influence of other risk factors before making their evaluation about the possible relationship between smoking and these cancers.

When all the numbers had been crunched, it was discovered that nurses in the study who smoked had increased their overall chances of contracting breast cancer by 6%. Relatively speaking, this is not a huge increase, and it would not qualify smoking as a strong causal factor for breast cancer. But among women who had smoked regularly for the entire period of the survey, the increased incidence  of breast cancer was a much more significant 28%.

The second important study on smoking and breast cancer was published in the British Medical Journal in March of 2011. The Woman's Health Initiative involved almost 80,000 women between the ages of 50 and 75, approximately 3,250 of whom were diagnosed with breast cancer during a ten-year period of regular check ups following the initial collection of health data. The women who participated in the study were broken up into four groups:

  • Those who smoked
  • Those who smoked at one time but had quit
  • Those who had been exposed to second hand smoke for a significant period of time
  • Those who have never smoked

The study showed that active smoking and extensive passive smoking were associated with a significantly increased risk of breast cancer in postmenopausal women. These results support the recent conclusions of top expert panels that breast cancer must be added to the list of target organs that are affected by tobacco smoke. Interestingly, earlier research has shown that smoking is associated with lower participation in mammography screening.

The findings of the study are summarized below:

  1. Women who developed breast cancer were less likely to have been non-smokers.
  2. Among lifetime non-smokers, 88.1% were exposed to passive smoking, and most women had multiple types of passing smoking exposure.
  3. There is an elevated risk of breast cancer in former smokers (9%) and current smokers (16%), particularly with a long smoking history that started at an early age.
  4. A 32% excess risk of breast cancer was associated with the most extensive exposure to passive smoking among women who never smoked.
  5. Women who developed breast cancer were slightly older than women who did not, but their body mass index was similar.
  6. Women who developed breast cancer were likely to be non-Hispanic white, more highly educated, with a history of taking hormone replacement therapy, a history of alcohol intake, and a family history of breast cancer.

The Evidence is In
These two important research studies would seem to indicate that smoking can now officially be listed as a risk factor for breast cancer. In addition, the second study also appears to establish a significant connection to breast cancer and second hand smoke, although this still needs to be explored further.

Get Help to Quit Smoking
Debate may well continue about the relative strength of smoking as a risk factor for breast cancer, especially when compared to other well-known risks. But given the firmly established links that exist between smoking and innumerable other serious health conditions, any lingering uncertainty over the smoking-breast cancer connection is hardly a reason for any woman to resist giving up this dangerous and addictive habit.

Visit Smokefree.gov, a website created by National Cancer Institute’s Tobacco Control Research Unit, for valuable information, tools and support that can help you quit smoking.

 

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