Hormone Therapy
Breast cancer cells, more often than not, have receptors on their surfaces that allow them to capture and use the female hormones estrogen and progesterone as a source of nourishment and energy that can help to fuel cancer cell division and growth. About 75- 80% of all breast cancers test positive for estrogen receptors, and about two-thirds of these also test positive for progesterone receptors. Cancer researchers have used this knowledge to help create drugs that can block the actions of hormone-receptor positive cells by attaching to the receptors and cutting off the food supply to those particular cells, which can cause these cells to shrivel up and die. These drugs are known as estrogen receptor modulators (SERM), and a drug called Tamoxifen is by far the most commonly prescribed type of SERM used to disrupt the process by which cancer cells capture female hormones and convert them into energy.
There is another class of drugs used in hormone therapy called aromatase inhibitors. These chemicals are prescribed for postmenopausal breast cancer patients because of their ability to block the actions of the enzyme that releases estrogen from the fat cells of the body (the exclusive source of estrogen for women who are no longer producing it in the ovaries).
Targeted Drug Therapy
The third use of drugs for breast cancer treatment is in targeted therapy. In this case, drugs are prescribed for patients because of their ability to attack specific characteristics that exist in certain types of breast cancer cells. Probably the two most well-known drugs used in targeted therapy are Herceptin and Tykerb, both of which are used against a protein called human growth factor receptor 2 (HER2). Found in abundance on the surfaces of many breast cancer cells, this protein helps cancer cells divide and grow; but drugs like those just mentioned are capable of interrupting and interfering with this process, which can ultimately cause HER2 positive cancer cells to shrink and disappear.
Research Efforts Continue
The search for drugs that can function as effective antidotes to cancer cell growth continues. Clinical trials are going on at every moment, and there is no doubt that new drugs will be developed in the future that will offer breast cancer patients more effective weapons that can be used to combat this stubborn and difficult disease.


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